The Mottram laboratory works on the molecular genetics, cell biology and biochemistry of the parasitic protozoa that cause neglected tropical diseases such as leishmaniasis and Human African Trypanosomiasis (HAT). The primary research goal of the laboratory is to understand the molecular mechanisms by which Leishmania and Trypanosoma parasites undergo cellular remodelling during their complex life cycles. The laboratory’s focus is on cell signalling pathways that are regulated by protein kinases and the turnover of proteins and organelles that occur through the action of peptidases associated with endocytic and autophagic pathways. The laboratory is also interested in virulence factors that influence the host-parasite interaction, natural variation in the Leishmania genome and new methods for monitoring disease progression. Our ultimate goal is to identify novel molecular mechanisms that can be exploited for the development of anti-parasite therapies.

Congratulations to Manuel for his artwork on the cover of Nature Microbiology

September 24, 2020

Our new article, "Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors", showcases recent work into the mechanism of action of AB1, an inhibitor with potent activity against Trypanosoma brucei bloodstream forms, Leishmania and Trypanosoma cruzi. 

Good representation from the Mottram lab at the 3rd Advanced School in genetic manipulation of parasitic protozoa

March 31, 2019

There was good attendance at the IICB in Kolkata, India (March 2019) where Nathaniel Jones and Nicola Baker gave a practical demonstration of CRISPR-Cas9 editing in Leishmania.


Regarding the course, Professor Mottram said: “CRIPSR genome editing transforms how we identify and validate new drug targets for neglected tropical diseases, such as leishmaniasis. The workshop in Kolkata provided theoretical and hands-on training in Leishmania gene manipulation, allowing students to extend the technology into their own research programs. The success of the workshops in Rio de Janeiro and Kolkata are inspiring us to hold further training for researchers from developing countries”.

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