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2024

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2023

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  • Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.  Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT.Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29.PMID: 37384702

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  • Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery.  Russell CN, Carter JL, Borgia JM, Bush J, Calderón F, Gabarró R, Conway SJ, Mottram JC, Wilkinson AJ, Jones NG.  ACS Infect Dis. 2023 Nov 10;9(11):2340-2357.doi: 10.1021/acsinfecdis.3c00431. Epub 2023 Oct 31.
     

  • Autophagy in protists and their hosts: When, how and why?  Romano PS, Akematsu T,  Besteiro S, Bindschedler A, Carruthers VB, Chahine Z, Coppens I, Descoteaux A, Duque TLA, He CY, Heussler V,  Le Roch KG, Li F-J, de Menezes JPB, Menna-Barreto RFS, Mottram JC 13, Schmuckli-Maurer J, Turk B, Veras PST, Salassa BN,  Vanrell MC.  Autophagy Rep. 2023;2(1):2149211. doi: 10.1080/27694127.2022.2149211. Epub 2023 Mar 9.​​

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2022

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2021

  • Candidates for Balancing Selection in Leishmania donovani Complex Parasites.  Grace CA, Forrester S, Silva VC, Carvalho KSS, Kilford H, Chew YP, James S, Costa DL, Mottram JC, Costa CCHN, Jeffares DC. Genome Biol Evol. 2021 Dec 1;13(12):evab265. doi: 10.1093/gbe/evab265.
     

  • 17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death.  Petersen ALOA, Cull B, Dias BRS, Palma LC, Luz YDS, de Menezes JPB, Mottram JC, Veras PST.  Microorganisms. 2021 May 19;9(5):1089. doi: 10.3390/microorganisms9051089.
     

  • A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei.  Saldivia M, Wollman AJM,  Carnielli JBT,  Jones NG,  Leake MC, Bower-Lepts C, Rao SPS,  JC,  ASMJournals mBio 12(3) doi.org/10.1128/mBio.00687-21

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  • Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host.  Levy DJ, Goundry A, Laires RSS, Costa TFR, Novo CM, Grab DJ, Mottram JC, Lima APCA. PLOS Neglected Tropical Diseases. 15(6):e0009526. doi: 10.1371/journal.pntd.0009526. 

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  • The kinesin of the flagellum attachment zone in Leishmania is required for cell morphogenesis, cell division and virulence in the mammalian host.  Corrales RM, Vaselek S, Neish R, Berry L, Brunet CD, Crobu L, Kuk N, Mateos-Langerak  J, Robinson DR, Volf  P,  Mottram JC, Sterkers Y, Bastien P.  PLOS Pathogens 17(6):e1009666. doi.org/10.1371/journal.ppat.1009666

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  • Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. McNae IW, Kinkead J, Malik D, Yen L-H, Walker MK, Swain C, Webster SP, Gray N, Fernandes PM, Myburgh E, Blackburn EA, Ritchie R, Austin C, Wear MA, Highton AJ, Keats AJ, Vong A, Dornan J, Mottram JC, Michels PAM, Pettit S, Walkinshaw MD. Nature Communications 12: 1052 doi.org/10.1038/s41467-021-21273-6

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  • Importance of Angomonas deanei KAP4 for kDNA arrangement, cell division and maintenance of the host-bacterium relationship.  Gonçalves CS, Catta-Preta CMC, Repolês B, Mottram JC, De Souza W, Machado R, Motta MCM. Scientific Reports 11 (1):9210 doi.org/10.1038/s41598-021-88685-8

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  • Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival. Baker N, Catta-Preta CMC, Neish R, Sadlova J, Powell B, Alves-Ferreira EVC, Geoghegan V, Carnielli JBT, Newling K,  Hughes C, Vojtkova B, Anand J, Mihut A, Walrad PB, Wilson LG, Pitchford JW, Volf P, Mottram JC.  Nature Communications 12:1244 doi.org/10.1038/s41467-021-21360-8

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  • Chromosomal assembly of the nuclear genome of the endosymbiont-bearing trypanosomatid Angomonas deanei.  Davey JW, Catta-Preta CMC, James S, Forrester S, Motta MCM, Ashton PD, Mottram JC.  G3 Genes/Genomes/Genetcis 11(1):jkaa018. doi: 10.1093/g3journal/jkaa018. PMID: 33561222

2020

  • ​​​Role for the flagellum attachment zone in Leishmania anterior cell tip morphogenesis.  Halliday C, Yanase R, Catta-Preta CMC, Moreira-Leite F, Myskova J, Pruzinova K, Volf P, Mottram JC, Sunter JD. PLOS Pathogens  16(10): e1008494. doi:10.1371/journal.ppat.1008494

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  • Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex. Burge RJ, Damianou A, Wilkinson AJ, Rodenko B, Mottram JC.  PLOS Pathogens 16(10): e1008784. doi:10.1371/journal.ppat.1008784

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  • Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Saldivia M, Fang E, Ma X, Myburgh E, Carnielli JBT, Bower-Lepts C, Brown E, Ritchie R, Lakshminarayana SB, Chen YL, Patra D, Ornelas E, Koh HXY, Williams SL, Supek F, Paape D, McCulloch R, Kaiser M, Barrett MP, Jiricek J, Diagana TT, Mottram JC, Rao SPS. Nat Microbiol. 2020 Oct;5(10):1207-1216. doi: 10.1038/s41564-020-0745-6. Epub 2020 Jul 13. PMID: 32661312

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  • Essential roles for deubiquitination in Leishmania life cycle progression. Damianou A, Burge RJ, Catta-Preta CMC, Geoghegan V, Nievas YR, Newling K, Brown E, Burchmore R, Rodenko B, Mottram JC. PLoS Pathog. 2020 Jun 16;16(6):e1008455. doi: 10.1371/journal.ppat.1008455. eCollection 2020 Jun. PMID: 32544189 

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  • In Vivo Bioluminescence Imaging to Assess Compound Efficacy Against Trypanosoma brucei. Ritchie R, Barrett MP, Mottram JC, Myburgh E. Methods Mol Biol. 2020;2116:801-817. doi: 10.1007/978-1-0716-0294-2_48. PMID: 32221957

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  • Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi CJ, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemenčič M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, van der Hoorn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV. Mol Cell. 2020 Mar 5;77(5):927-929. doi: 10.1016/j.molcel.2019.12.020. PMID: 32142688

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  • New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story. Dickie EA, Giordani F, Gould MK, Mäser P, Burri C, Mottram JC, Rao SPS, Barrett MP. Trop Med Infect Dis. 2020 Feb 19;5(1):29. doi: 10.3390/tropicalmed5010029. PMID: 32092897 

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  • Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis. Rao SPS, Lakshminarayana SB, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Mäser P, Mottram JC, Barrett MP, Diagana TT. Trop Med Infect Dis. 2020 Feb 17;5(1):28. doi: 10.3390/tropicalmed5010028. PMID: 32079320 

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  • Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens. Black JA, Crouch K, Lemgruber L, Lapsley C, Dickens N, Tosi LRO, Mottram JC, McCulloch R.
    Cell Rep. 2020 Jan 21;30(3):836-851.e5. doi: 10.1016/j.celrep.2019.12.049. PMID: 31968257

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2019

  • Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis. Forrester S, Siefert K, Ashwin H, Brown N, Zelmar A, James S, Lagos D, Timmis J, Chatterjee M, Mottram JC, Croft SL, Kaye PM. Wellcome Open Res. 2019 Dec 10;4:198. doi: 10.12688/wellcomeopenres.15606.1. eCollection 2019. PMID: 31976381

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  • Evaluation of clan CD C11 peptidase PNT1 and other Leishmania mexicana cysteine peptidases as potential drug targets. Grewal JS, Catta-Preta CMC, Brown E, Anand J, Mottram JC. Biochimie. 2019 Nov;166:150-160. doi: 10.1016/j.biochi.2019.08.015. Epub 2019 Aug 28. PMID: 31472179

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  • Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil. Carnielli JBT, Monti-Rocha R, Costa DL, Molina Sesana A, Pansini LNN, Segatto M, Mottram JC, Costa CHN, Carvalho SFG, Dietze R. Am J Trop Med Hyg. 2019 Oct;101(4):789-794. doi: 10.4269/ajtmh.18-0949. PMID: 31436148

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  • Neutrophil elastase promotes Leishmania donovani infection via interferon-β. Dias BT, Dias-Teixeira KL, Godinho JP, Faria MS, Calegari-Silva T, Mukhtar MM, Lopes U, Mottram JC, Lima APCA. FASEB J. 2019 Oct;33(10):10794-10807. doi: 10.1096/fj.201900524R. Epub 2019 Jul 5. PMID: 31284755

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  • DiCre-Based Inducible Gene Expression. Damasceno JD, Tosi LRO, Santos RERS, Mottram JC. Methods Mol Biol. 2019;1971:225-235. doi: 10.1007/978-1-4939-9210-2_11. PMID: 30980306

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  • DiCre-Based Inducible Disruption of Leishmania Genes. Duncan SM, Myburgh E, Alves-Ferreira EV, Mottram JC. Methods Mol Biol. 2019;1971:211-224. doi: 10.1007/978-1-4939-9210-2_10. PMID: 30980305

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  • Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host. Sunter JD, Yanase R, Wang Z, Catta-Preta CMC, Moreira-Leite F, Myskova J, Pruzinova K, Volf P, Mottram JC, Gull K. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6351-6360. doi: 10.1073/pnas.1812462116. Epub 2019 Mar 8. PMID: 30850532 

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  • Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis. Ashwin H, Seifert K, Forrester S, Brown N, MacDonald S, James S, Lagos D, Timmis J, Mottram JC, Croft SL, Kaye PM. Version 2. Wellcome Open Res. 2019 Jan 2 [revised 2019 Jan 1];3:135. doi: 10.12688/wellcomeopenres.14867.2. eCollection 2018. PMID: 30542664 

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  • TLR2 Signaling in Skin Nonhematopoietic Cells Induces Early Neutrophil Recruitment in Response to Leishmania major Infection. Ronet C, Passelli K, Charmoy M, Scarpellino L, Myburgh E, Hauyon La Torre Y, Turco S, Mottram JC, Fasel N, Luther SA, Beverley SM, Launois P, Tacchini-Cottier F. J Invest Dermatol. 2019 Jun;139(6):1318-1328. doi: 10.1016/j.jid.2018.12.012. Epub 2018 Dec 27. PMID: 30594488​​

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2018

  • A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis. Carnielli JBT, Crouch K, Forrester S, Silva VC, Carvalho SFG, Damasceno JD, Brown E, Dickens NJ, Costa DL, Costa CHN, Dietze R, Jeffares DC, Mottram JC. EBioMedicine. 2018 Oct;36:83-91. doi: 10.1016/j.ebiom.2018.09.029. Epub 2018 Sep 27. PMID: 30268832 

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  • Drug candidate and target for leishmaniasis. Catta-Preta CMC, Mottram JC. Nature. 2018 Aug;560(7717):171-172. doi: 10.1038/d41586-018-05765-y. No abstract available. PMID: 30076375

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  • Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects. Jones NG, Catta-Preta CMC, Lima APCA, Mottram JC. ACS Infect Dis. 2018 Apr 13;4(4):467-477. doi: 10.1021/acsinfecdis.7b00244. Epub 2018 Feb 9. PMID: 29384366

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  • Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification. Bussotti G, Gouzelou E, Côrtes Boité M, Kherachi I, Harrat Z, Eddaikra N, Mottram JC, Antoniou M, Christodoulou V, Bali A, Guerfali FZ, Laouini D, Mukhtar M, Dumetz F, Dujardin JC, Smirlis D, Lechat P, Pescher P, El Hamouchi A, Lemrani M, Chicharro C, Llanes-Acevedo IP, Botana L, Cruz I, Moreno J, Jeddi F, Aoun K, Bouratbine A, Cupolillo E, Späth GF. MBio. 2018 Nov 6;9(6). pii: e01399-18. doi: 10.1128/mBio.01399-18. PMID: 30401775.

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  • Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells. Goundry A, Romano A, Lima APCA, Mottram JC, Myburgh E. FASEB J. 2018 Mar;32(3):1315-1327. doi: 10.1096/fj.201700797R. Epub 2018 Jan 3. PMID: 29097502 

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  • New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8. Fey P, Chartomatsidou R, Kiefer W, Mottram JC, Kersten C, Schirmeister T. Eur J Med Chem. 2018 Aug 5;156:587-597. doi: 10.1016/j.ejmech.2018.07.012. Epub 2018 Jul 9. PMID: 30029081

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2017

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  • A DiCre recombinase-based system for inducible expression in Leishmania major.  Santos RERS, Silva GLA, Santos EV, Duncan SM, Mottram JC, Damasceno JD, Tosi LRO J. Mol Biochem Parasitol. 2017 Jun 16;216:45-48. doi: 10.1016/j.molbiopara.2017.06.006.

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  • Recent advances in Leishmania reverse genetics: Manipulating a manipulative parasite. Duncan SM, Jones NG, Mottram JC. Mol Biochem Parasitol. 2017 Jun 16;216:30-38. doi: 10.1016/j.molbiopara.2017.06.005

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  • The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei. Rojas F, Koszela J, Búa J, Llorente B, Burchmore R, Auer M, Mottram JC, Téllez-Iñón MT.  PLoS Negl Trop Dis. 2017 Jun 13;11(6):e0005626. doi: 10.1371/journal.pntd.0005626. eCollection 2017 Jun.

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2016

  • Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis. Biéler S, Waltenberger H, Barrett MP, McCulloch R, Mottram JC, Carrington M, Schwaeble W, McKerrow J, Phillips MA, Michels PA, Büscher P, Sanchez JC, Bishop R, Robinson DR, Bangs J, Ferguson M, Nerima B, Albertini A, Michel G, Radwandska M, Ndung'u JM. PLoS One. 2016 Dec 9;11(12):e0168074. doi: 10.1371/journal.pone.0168074. eCollection 2016. PMID: 27936225 

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  • Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium. Catta-Preta CM, Dos Santos Pascoalino B, de Souza W, Mottram JC, Motta MC, Schenkman S. J Eukaryot Microbiol. 2016 Nov;63(6):794-803. doi: 10.1111/jeu.12326. Epub 2016 Jun 16. PMID: 27194398 

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  • Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness. Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, Barnes SW, Mathison CJ, Myburgh E, Gao MY, Gillespie JR, Liu X, Tan JL, Stinson M,   Rivera IC, Ballard J, Yeh V, Groessl T, Federe G, Koh HX, Venable JD, Bursulaya B, Shapiro M, Mishra PK, Spraggon G, Brock A, Mottram JC, Buckner FS, Rao SP, Wen BG, Walker JR, Tuntland T, Molteni V, Glynne RJ, Supek F. Nature. 2016 Aug 8;537(7619):229-233. doi: 10.1038/nature19339

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  • Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation. Duncan SM, Myburgh E, Philipon C, Brown E, Meissner M, Brewer J, Mottram JC. Mol Microbiol. 2016 Jun;100(6):931-44. doi: 10.1111/mmi.13375. 

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  • Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium. Catta-Preta CM, Pascoalino BD, de Souza W, Mottram JC, Motta M Schenkman S. J Eukaryot Microbiol. 2016 May 19. doi: 10.1111/jeu.12326​

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  • PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast. Grewal JS, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, Lemgruber L, Gould MK, Burchmore RJ, Coombs GH, Schnaufer A, Mottram JC. J Biol Chem. 2016 Apr 29;291(18):9492-500. doi: 10.1074/jbc.M116.714972.

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  • Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome. McLuskey K, Grewal JS, Das D, Godzik A, Lesley SA, Deacon AM, Coombs GH, Elsliger MA, Wilson IA, Mottram JC. J Biol Chem. 2016 Apr 29;291(18):9482-91. doi: 10.1074/jbc.M115.706143. Epub 2016 Mar 3. PMID: 26940874

 

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky, D. J., Abdelmohsen K, Mottram, J. C. and 2,450 other authors. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PMID: 26799652

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