2019

  • Evaluation of clan CD C11 peptidase PNT1 and other Leishmania mexicana cysteine peptidases as potential drug targets. Grewal JS, Catta-Preta CMC, Brown E, Anand J, Mottram JC. Biochimie. 2019 Nov;166:150-160. doi: 10.1016/j.biochi.2019.08.015. Epub 2019 Aug 28. PMID: 31472179

  • Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil. Carnielli JBT, Monti-Rocha R, Costa DL, Molina Sesana A, Pansini LNN, Segatto M, Mottram JC, Costa CHN, Carvalho SFG, Dietze R. Am J Trop Med Hyg. 2019 Oct;101(4):789-794. doi: 10.4269/ajtmh.18-0949. PMID: 31436148

  • Neutrophil elastase promotes Leishmania donovani infection via interferon-β. Dias BT, Dias-Teixeira KL, Godinho JP, Faria MS, Calegari-Silva T, Mukhtar MM, Lopes U, Mottram JC, Lima APCA. FASEB J. 2019 Oct;33(10):10794-10807. doi: 10.1096/fj.201900524R. Epub 2019 Jul 5. PMID: 31284755

  • DiCre-Based Inducible Gene Expression. Damasceno JD, Tosi LRO, Santos RERS, Mottram JC. Methods Mol Biol. 2019;1971:225-235. doi: 10.1007/978-1-4939-9210-2_11. PMID: 30980306

  • DiCre-Based Inducible Disruption of Leishmania Genes. Duncan SM, Myburgh E, Alves-Ferreira EV, Mottram JC. Methods Mol Biol. 2019;1971:211-224. doi: 10.1007/978-1-4939-9210-2_10. PMID: 30980305

  • Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host. Sunter JD, Yanase R, Wang Z, Catta-Preta CMC, Moreira-Leite F, Myskova J, Pruzinova K, Volf P, Mottram JC, Gull K. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6351-6360. doi: 10.1073/pnas.1812462116. Epub 2019 Mar 8. PMID: 30850532 

  • Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis. Ashwin H, Seifert K, Forrester S, Brown N, MacDonald S, James S, Lagos D, Timmis J, Mottram JC, Croft SL, Kaye PM. Version 2. Wellcome Open Res. 2019 Jan 2 [revised 2019 Jan 1];3:135. doi: 10.12688/wellcomeopenres.14867.2. eCollection 2018. PMID: 30542664 

  • TLR2 Signaling in Skin Nonhematopoietic Cells Induces Early Neutrophil Recruitment in Response to Leishmania major Infection. Ronet C, Passelli K, Charmoy M, Scarpellino L, Myburgh E, Hauyon La Torre Y, Turco S, Mottram JC, Fasel N, Luther SA, Beverley SM, Launois P, Tacchini-Cottier F. J Invest Dermatol. 2019 Jun;139(6):1318-1328. doi: 10.1016/j.jid.2018.12.012. Epub 2018 Dec 27. PMID: 30594488​​

  • Drug Discovery for Kinetoplastid Diseases: Future Directions. Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT. ACS Infect Dis. 2019 Feb 8;5(2):152-157. doi: 10.1021/acsinfecdis.8b00298. Epub 2018 Dec 13. PMID: 30543391

2018

  • A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis. Carnielli JBT, Crouch K, Forrester S, Silva VC, Carvalho SFG, Damasceno JD, Brown E, Dickens NJ, Costa DL, Costa CHN, Dietze R, Jeffares DC, Mottram JC. EBioMedicine. 2018 Oct;36:83-91. doi: 10.1016/j.ebiom.2018.09.029. Epub 2018 Sep 27. PMID: 30268832 

  • Drug candidate and target for leishmaniasis. Catta-Preta CMC, Mottram JC. Nature. 2018 Aug;560(7717):171-172. doi: 10.1038/d41586-018-05765-y. No abstract available. PMID: 30076375

  • Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects. Jones NG, Catta-Preta CMC, Lima APCA, Mottram JC. ACS Infect Dis. 2018 Apr 13;4(4):467-477. doi: 10.1021/acsinfecdis.7b00244. Epub 2018 Feb 9. PMID: 29384366

  • Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification. Bussotti G, Gouzelou E, Côrtes Boité M, Kherachi I, Harrat Z, Eddaikra N, Mottram JC, Antoniou M, Christodoulou V, Bali A, Guerfali FZ, Laouini D, Mukhtar M, Dumetz F, Dujardin JC, Smirlis D, Lechat P, Pescher P, El Hamouchi A, Lemrani M, Chicharro C, Llanes-Acevedo IP, Botana L, Cruz I, Moreno J, Jeddi F, Aoun K, Bouratbine A, Cupolillo E, Späth GF. MBio. 2018 Nov 6;9(6). pii: e01399-18. doi: 10.1128/mBio.01399-18. PMID: 30401775.

  • Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells. Goundry A, Romano A, Lima APCA, Mottram JC, Myburgh E. FASEB J. 2018 Mar;32(3):1315-1327. doi: 10.1096/fj.201700797R. Epub 2018 Jan 3. PMID: 29097502 

  • New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8. Fey P, Chartomatsidou R, Kiefer W, Mottram JC, Kersten C, Schirmeister T. Eur J Med Chem. 2018 Aug 5;156:587-597. doi: 10.1016/j.ejmech.2018.07.012. Epub 2018 Jul 9. PMID: 30029081

​​

2017

  • A DiCre recombinase-based system for inducible expression in Leishmania major.  Santos RERS, Silva GLA, Santos EV, Duncan SM, Mottram JC, Damasceno JD, Tosi LRO J. Mol Biochem Parasitol. 2017 Jun 16;216:45-48. doi: 10.1016/j.molbiopara.2017.06.006.

  • Recent advances in Leishmania reverse genetics: Manipulating a manipulative parasite. Duncan SM, Jones NG, Mottram JC. Mol Biochem Parasitol. 2017 Jun 16;216:30-38. doi: 10.1016/j.molbiopara.2017.06.005

  • The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei. Rojas F, Koszela J, Búa J, Llorente B, Burchmore R, Auer M, Mottram JC, Téllez-Iñón MT.  PLoS Negl Trop Dis. 2017 Jun 13;11(6):e0005626. doi: 10.1371/journal.pntd.0005626. eCollection 2017 Jun.

 

 

2016

  • Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis. Biéler S, Waltenberger H, Barrett MP, McCulloch R, Mottram JC, Carrington M, Schwaeble W, McKerrow J, Phillips MA, Michels PA, Büscher P, Sanchez JC, Bishop R, Robinson DR, Bangs J, Ferguson M, Nerima B, Albertini A, Michel G, Radwandska M, Ndung'u JM. PLoS One. 2016 Dec 9;11(12):e0168074. doi: 10.1371/journal.pone.0168074. eCollection 2016. PMID: 27936225 

  • Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium. Catta-Preta CM, Dos Santos Pascoalino B, de Souza W, Mottram JC, Motta MC, Schenkman S. J Eukaryot Microbiol. 2016 Nov;63(6):794-803. doi: 10.1111/jeu.12326. Epub 2016 Jun 16. PMID: 27194398 

  • Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness. Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, Barnes SW, Mathison CJ, Myburgh E, Gao MY, Gillespie JR, Liu X, Tan JL, Stinson M,   Rivera IC, Ballard J, Yeh V, Groessl T, Federe G, Koh HX, Venable JD, Bursulaya B, Shapiro M, Mishra PK, Spraggon G, Brock A, Mottram JC, Buckner FS, Rao SP, Wen BG, Walker JR, Tuntland T, Molteni V, Glynne RJ, Supek F. Nature. 2016 Aug 8;537(7619):229-233. doi: 10.1038/nature19339

  • Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation. Duncan SM, Myburgh E, Philipon C, Brown E, Meissner M, Brewer J, Mottram JC. Mol Microbiol. 2016 Jun;100(6):931-44. doi: 10.1111/mmi.13375. 

  • Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium. Catta-Preta CM, Pascoalino BD, de Souza W, Mottram JC, Motta M Schenkman S. J Eukaryot Microbiol. 2016 May 19. doi: 10.1111/jeu.12326

  • PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast. Grewal JS, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, Lemgruber L, Gould MK, Burchmore RJ, Coombs GH, Schnaufer A, Mottram JC. J Biol Chem. 2016 Apr 29;291(18):9492-500. doi: 10.1074/jbc.M116.714972.

  • Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome. McLuskey K, Grewal JS, Das D, Godzik A, Lesley SA, Deacon AM, Coombs GH, Elsliger MA, Wilson IA, Mottram JC. J Biol Chem. 2016 Apr 29;291(18):9482-91. doi: 10.1074/jbc.M115.706143. Epub 2016 Mar 3. PMID: 26940874

 

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky, D. J., Abdelmohsen K, Mottram, J. C. and 2,450 other authors. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PMID: 26799652 

Department of Biology
University of York

Heslington, York, YO10 5DD, UK 

jmottramgroup@gmail.com