Jeremy Mottram

Jeremy Mottram is Professor in Pathogen Biology and director of the York Biomedical Research Institute. He trained as a biochemist at the University of Kent at Canterbury (BSc) and the University of Glasgow (PhD) before carrying out postdoctoral work at the University of California San Francisco in molecular parasitology, with a focus on gene expression and RNA splicing in African trypanosomes.  He returned to Glasgow for further postdoctoral research in the newly formed Wellcome Unit of Molecular Parasitology, before developing an independent molecular parasitology research programme as an MRC Senior Research Fellow (1993-2003), being appointed Professor of Molecular and Cellular Parasitology in 2000.  In Glasgow Jeremy served as Head of the Division of Infection and Immunity (2008-2010), Deputy Director of the Institute of Infection, Immunity and Inflammation (2010-2013) and Dean of Graduate Studies (2013–2015). He joined the Department of Biology at the University of York in 2016. He has been a member of the MRC Infections and Immunity Board (2010–2014) and has been on both national and international review boards for the Institute Pasteur, INSERM and NIMR. Jeremy is a Fellow of the Royal Society of Edinburgh, a Fellow of the Royal Society of Biology and a Pesquisador Visitante Especial, Universidade Federal do Rio de Janeiro, Brazil.

jeremy.mottram@york.ac.uk

Nathaniel Jones

Nathaniel is a GCRF NTD Network Research Fellow. He is working to validate epigenetic reader proteins of Leishmania as new drug targets. Several of these targets are being characterised using genetic, proteomic, biochemical and structural techniques. This work has been supported in part by the pharmaceutical company GSK and it is hoped that these targets can be validated using chemical probes from this collaboration. Nathaniel previously worked on protein kinases in Trypanosoma brucei and Toxoplasma gondii, investigating them as potential drug targets and virulence factors.

nathaniel.jones@york.ac.uk

Jayanthi Anand

Jayanthi is a Senior Research Technician in Professor Jeremy Mottram's group. She did her B.Pharm and Masters (in Biotechnology) degree in India and obtained her PhD (Dr. rer. nat) in Cell Biology from Albert-Ludwigs University of Freiburg, Germany. Her research mainly focused on immunological aspects of bone marrow transplantation, graft versus host disease and on anti-cancer therapeutics. After exploring and supporting research in industry (FMI-Part of NIBR-Novartis and ProQinase GmbH) she moved to the Mottram group and since May 2016 she is supporting the projects that deal with development of drugs for parasitic diseases. 

jayanthi.anand@york.ac.uk

Rebecca Burge

Rebecca obtained her BSc(Hons) in Genetics with Industrial Experience from The University of Manchester in 2016. Her undergraduate course included a one year research placement at Boehringer Ingelheim in Germany. She joined the Mottram lab as a PhD researcher in 2016, where she is investigating the role of the ubiquitin system in Leishmania with a particular focus on E1, E2 and E3 enzymes. During the third year of her PhD she carried out a 3-month internship at the biotechnology company Ubiquigent Ltd. Her project is funded by an MRC iCASE studentship in association with the industrial partner UbiQ.

rjb595@york.ac.uk

Vincent Geoghegan

Vincent is a post-doctoral research associate in the lab of Prof. Jeremy Mottram. He has an M.Biochem. from the University of Oxford and a D.Phil. from the Sir William Dunn School of Pathology at the University of Oxford where he investigated the role of protein arginine methylation in T-lymphocyte activation using mass spectrometry based proteomics, under the supervision of Prof. Oreste Acuto. Subsequently, working under Prof. Steven Sinkins at the University of Lancaster and University of Glasgow, he applied his experience of proteomics to investigate Wolbachia-host interactions and the mechanism of viral inhibition induced by this bacterium. In the Mottram lab, he is applying genetic tagging and proteomics to characterise Leishmania kinases.

vincent.geoghegan@york.ac.uk

Rachel Neish

Rachel is a postdoc working on the kinase project.

rachel.neish@york.ac.uk

Juliana Brambilla Carnielli Trindade

Juliana is a Postdoctoral Research Associate in the Mottram lab. Juliana obtained her Bachelors in Pharmacist-Biochemist (2008) and her MSc (2011) in Infection Disease from the Universidade Federal do Espírito Santo (UFES), Brazil. She completed her PhD (2015) within the UFES with one year of sandwich program in the Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation at the University of Glasgow. Currently, Juliana is investigating molecular markers associated with natural miltefosine resistance in the Leishmania parasite.

juliana.carnielli@york.ac.uk

Catherine Russell

Catherine graduated from the University of York in 2018 with an Integrated Master’s degree in Biochemistry, MBiochem (Hons). Her undergraduate course included a one-year research project in the field of infection and immunity at the University of Sheffield, and her final year research project in York Structural Biology Laboratory involved structural analysis of a microbial enzyme. Catherine subsequently began a BBSRC funded PhD project in 2018 under the supervision of Prof Jeremy Mottram and Prof Tony Wilkinson. Her research combines structural biology and parasitology to investigate epigenetic reader domains in Leishmania as new drug targets in the treatment of leishmaniasis.

cr831@york.ac.uk

Romina Nievas

Romina is a postdoc working on the kinase project.

romina.nievas@york.ac.uk

Charlotte Hughes

Charlotte is a Research Technician in the Mottram lab. She obtained her Bsc(Hons) in Biochemistry with an Industrial Placement year in 2019 from the University of Bath. Her undergraduate course involved a year researching lysosomal storage disorders at Cardiff University. She joined the lab in 2019, primarily to assist research on the Kinome project, particularly supporting the work of Nicola Baker with characterising a range of protein kinases in Leishmania

charlotte.hughes@york.ac.uk

Sergios Antoniou

Sergios joined Prof Jeremy Mottram's lab as a PhD student in 2019. He obtained his BSc (Hons) in Biology from the University of York in 2019. For his final year research project during his undergraduate studies he investigated possible novel kinetochore proteins in Leishmania mexicana, also in the Mottram lab. Currently he is trying to elucidate the function and essentiality of deubiquitinases in L. mexicana and how these proteins are implicated in the differentiation process of this particular parasite. His four-year PhD project is fully funded by the Department of Biology of the University of York.

sa1361@york.ac.uk

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Department of Biology
University of York

Heslington, York, YO10 5DD, UK 

jmottramgroup@gmail.com