November 2022
Congratulations to Manuel for his artwork on the cover of Trends in Parasitology
Our new review together with Mathieu Cayla and Keith Matthews, "Distinguishing functions of trypanosomatid protein kinases", showcases the activity of protein kinases that are required for successful life cycle transitions in trypanosomatid parasitic protozoa.  Congratulations to Romina for the extensive comparative analysis shown in figure 1.

Our new article, "Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors", showcases recent work into the mechanism of action of AB1, an inhibitor with potent activity against Trypanosoma brucei bloodstream forms, Leishmania and Trypanosoma cruzi. 

For the course, Nathaniel Jones and Nicola Baker gave a practical demonstration of CRISPR-Cas9 editing in Leishmania.

Regarding the course, Professor Mottram said: “CRIPSR genome editing transforms how we identify and validate new drug targets for neglected tropical diseases, such as leishmaniasis. The workshop in Kolkata provided theoretical and hands-on training in Leishmania gene manipulation, allowing students to extend the technology into their own research programs.  The success of the workshops in Rio de Janeiro and Kolkata are inspiring us to hold further training for researchers from developing countries.”